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VOL. 10, ISSUE 2 (2026)
Phytochemical study using HPLC-ESI-QTOF and FT-IR, antioxidant activity of aqueous and hydroethanolic extracts of three traditional medicines PN, MChim, MChim2
Authors
Akoubet-Ouayogode Aminata, N'guessan Ocho Esther, Kablan Ahmont Landry Claude, Kablan Richmond Jean -François, Adiko N'dri Marceline
Abstract
Diabetes is a major health issue in Ivory
Coast. Traditional remedies, often made from plants, are used to treat this condition.
However, the chemical composition of these remedies and their ability to fight
free radicals remain poorly understood. This study aims to evaluate antioxidant
activity by DPPH and ABTS tests, to identify the families of compounds present
in the extracts by infrared and to carry out a chemical study by HPLC-ESI-QTOF-MS/ MS for the traditional medicine Mchim.
All three extracts exhibit significant free radical scavenging activity, with
an inhibitory concentration at 50% (IC50) of 2.01 ± 0.017
mg/ mL for the PN extract, 0.12 ± 0.02 mg/mL for the Mchim extract, and 0.097 ±
0.005 mg/ mL for Mchim2. At a concentration of 1.59 µM Trolox eq, the Mchim
extract inhibited 50.89% of the Abts radical. The amount of polyphenols is higher
in the Mchim extract ( 7.67 ± 0.28 mg GAE/g) compared to the PN extract ( 0.67
± 0.28 mg GAE/g). HPLC-ESI-QTOF-MS/MS analysis revealed the presence of
N1-acetylspermin in Mchim. Research shows that these traditional medicines
possess antioxidant activities. which could explain their use in the treatment
of diabetes.
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Pages:55-60
How to cite this article:
Akoubet-Ouayogode Aminata, N'guessan Ocho Esther, Kablan Ahmont Landry Claude, Kablan Richmond Jean -François, Adiko N'dri Marceline "Phytochemical study using HPLC-ESI-QTOF and FT-IR, antioxidant activity of aqueous and hydroethanolic extracts of three traditional medicines PN, MChim, MChim2". International Journal of Chemistry Studies, Vol 10, Issue 2, 2026, Pages 55-60
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