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VOL. 10, ISSUE 2 (2026)
Cassane diterpenoids from the root bark of Erythrophleum suaveolens (Guill. & Perr.) Brenan (Fabaceae)
Authors
Akoubet-Ouayogode Aminata, Konan Dibi Jacques, Kablan Ahmont Landry Claude, Kablan Richmond Jean-François, Attioua Koffi Barthelemy
Abstract
Cassane diterpenoids are among the major
secondary metabolites of the genus Erythrophleum suaveolens and are well
known for their diverse biological activities. In the present study, a
phytochemical investigation was carried out on the root bark of Erythrophleum
ivorense collected in Côte d’Ivoire. The methanolic extract was subjected
to acid-base partitioning, followed by successive chromatographic separations
including flash chromatography, Sephadex LH-20, silica gel column
chromatography, and semi-preparative HPLC. This work led to the isolation of
two cassane diterpenoid amines from the ethyl acetate fraction. Their
structures were elucidated by detailed spectroscopic analyses, including IR, 1H
and 13C NMR, HMBC, COSY, NOESY, and ESI-HRMS data. The isolated
compounds were identified as 3β-hydroxy-nor-erythrosuamine
(1) and 3β-hydroxy-nor-cassamidine (2). To the best of our knowledge,
compounds 1 and 2 are reported here for the first time from the root bark of Erythrophleum
ivorense. These findings contribute to the phytochemical knowledge of Erythrophleum
ivorense and further support the chemical diversity of cassane diterpenoids
in African medicinal plants.
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Pages:71-75
How to cite this article:
Akoubet-Ouayogode Aminata, Konan Dibi Jacques, Kablan Ahmont Landry Claude, Kablan Richmond Jean-François, Attioua Koffi Barthelemy "Cassane diterpenoids from the root bark of <i>Erythrophleum suaveolens</i> (Guill. & Perr.) Brenan (Fabaceae)". International Journal of Chemistry Studies, Vol 10, Issue 2, 2026, Pages 71-75
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