ARCHIVES
VOL. 9, ISSUE 2 (2025)
Determination of scanning electron microscopy and antimicrobial properties of 1,3,5 triazines derivatives with quinolines
Authors
Gopalkrushna H Murhekar, Kanchan Kumbhalkar
Abstract
The present study focuses on the determination of Scanning Electron
Microscopy (SEM) and antimicrobial properties of 1,3,5-triazine derivatives
containing quinoline moieties. A series of novel triazine derivatives were
synthesized through stepwise nucleophilic substitution reactions, where the
chlorine atoms of cyanuric chloride were sequentially replaced by quinoline and
substituted amines under controlled conditions. The synthesized compounds were
characterized by various physicochemical and spectral techniques, including
FT-IR, ¹H NMR, ¹³C NMR, UV-Visible, and Mass spectrometry, to confirm their
structural features and purity. The surface morphology of the selected triazine
derivatives was investigated using Scanning Electron Microscopy (SEM). The
micrographs revealed distinct surface textures, crystalline nature, and uniform
distribution, indicating the successful formation of well-defined molecular
architectures. The antimicrobial activity of the synthesized derivatives was
evaluated against selected Gram-positive and Gram-negative bacterial strains,
as well as fungal species, using the agar well diffusion method. Most compounds
exhibited moderate to significant inhibitory effects, particularly against
Staphylococcus aureus, Escherichia coli, and Candida albicans, suggesting that
the introduction of quinoline and substituted amine groups enhances biological
efficacy. the results demonstrate that 1,3,5-triazine derivatives incorporating
quinoline nuclei possess promising antimicrobial potential and well-defined
surface morphology, making them suitable candidates for further development in
pharmaceutical and material science applications.
Pages:41-44
How to cite this article:
Gopalkrushna H Murhekar, Kanchan Kumbhalkar "Determination of scanning electron microscopy and antimicrobial properties of 1,3,5 triazines derivatives with quinolines". International Journal of Chemistry Studies, Vol 9, Issue 2, 2025, Pages 41-44
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