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VOL. 9, ISSUE 2 (2025)
Formulation of a herbal antifungal cream with Sansevieria trifasciata and its efficacy against vaginal candidiasis
Authors
Molline K Kandiado, Adoren P Ngarivhume, Takudzwa D Chihombori
Abstract
Vaginal candidiasis also known as vaginal
yeast infection is a disease caused by candida albicans, a fungus that
is highly resistant after prolonged exposure to antifungals specifically
azoles. Vaginal candidiasis is very common and it affects 75% of women. The
overgrowth of candida albicans causes symptoms like itching, discomfort,
soreness, burning sensation and thick white discharge. The effectiveness of
antifungals like fluconazole is compromised by the emergence of resistance
candida strains, therefore there is a high demand for natural alternative
sources and Sansevieria trifasciata is a promising drug candidate. Sansevieria
trifasciata is an evergreen plant found in the tropical and subtropical
regions. It known for its medicinal properties and has been used to treat
diseases like ear aches, inflammation and it has antimicrobial properties. The
ethyl acetate extract of S Trifasciata is rich in several phytochemical
like saponins, phenols, terpenoids, flavonoids and tannins. These
phytochemicals were known to have antimicrobial activity and they were found
present in the extract. In this experiment the dried leaves were extracted
using the maceration method with ethyl acetate being the solvent of extraction.
The extract was quantified UV-VIS and the total phenolic and flavonoid contents
were calculated and got 500mgGAE/g and 100mgQE/g respectively. The extract was
characterized using FTIR and identified several functional groups that
correspond to phytochemicals like phenols, flavonoids and saponins. Bioassays
were conducted using the disc diffusion method and the extract got zones of
inhibition that were higher than those of the positive control which was
clotrimazole the negative control (ethyl acetate) had no zones of inhibition
meaning the activity shown by the extract was due to the bioactive compounds
found in the extract. Two creams were formulated and they were both stable
after the thermal cycle test there was no discoloration or melting. Both creams
got pH values that are within the recommended range for vaginal creams which is
3.8 to 5 This study confirms that Sansevieria trifasciata extract is a
promising antifungal drug that can be used as an alternative to azoles that are
in the market.
Pages:14-19
How to cite this article:
Molline K Kandiado, Adoren P Ngarivhume, Takudzwa D Chihombori "Formulation of a herbal antifungal cream with <i>Sansevieria trifasciata</i> and its efficacy against vaginal candidiasis". International Journal of Chemistry Studies, Vol 9, Issue 2, 2025, Pages 14-19
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