ARCHIVES
VOL. 9, ISSUE 1 (2025)
Identification of bioactive from Sansevieria Trifasciata Lauretii extract as antidiabetic type 2 in obesity Wistar rats
Authors
Maria Octaviani Kurniati*, Ni Wayan Bogoriani, I Made Sutha Negara
Abstract
Sansevieria Trifasciata Laurentii
is a plant known for its antioxidant properties, including polyphenols,
tannins, saponins, flavonoids, and steroids. This study aimed to investigate
the antidiabetic effects of a methanol extract from the leaves of the snake
plant in obese Wistar rats and to identify its bioactive constituents. A total
of 24 obese Wistar rats were administered doses of 100 and 200 mg/kg of the
methanol extract. The chemical composition of the extract was analyzed using
liquid chromatography-tandem mass spectrometry (LC-MS/MS). The results showed
that the methanol extract significantly reduced the levels of free fatty acids,
blood glucose, and triglycerides compared to the obese control group.
Specifically, the 100 and 200 mg/kg doses decreased triglyceride levels by
78.2% and 67.8%, respectively, while blood glucose levels were reduced by 47.7%
and 44.9%, respectively. Free fatty acid levels also decreased by 11.1% and
11.5% at the 100 and 200 mg/kg doses, respectively. LC-MS/MS analysis identified
five compounds in the methanol extract with potential antidiabetic properties:
anthranol, naringin, luteolin, quercetin, and sansevistatin 1. Based on these
findings, it was concluded that the five bioactive compounds identified in the
snake plant leaf extract showed promising antidiabetic activity.
Pages:7-11
How to cite this article:
Maria Octaviani Kurniati*, Ni Wayan Bogoriani, I Made Sutha Negara "Identification of bioactive from <i>Sansevieria Trifasciata Lauretii </i>extract as antidiabetic type 2 in obesity Wistar rats". International Journal of Chemistry Studies, Vol 9, Issue 1, 2025, Pages 7-11
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