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VOL. 8, ISSUE 1 (2024)
Nickel (II), cobalt (II) and lead (II) complexes of 4-hydroxy-3-methoxybenzaldehyde thiosemicarbazone synthesis; Characterization and antimicrobial activity
Authors
Mohammed Bahreldin Hussein, A Gobara, Mustafa Mohammad Ali Aldy
Abstract
This study was carried out for synthesis and
characterization of 4-Hydroxy-3-methoxybenzaldehyde thiosimcarbazone and its
Nickel (II), Cobalt (II) and Lead (II) complexes and to evaluate their
antimicrobial activity. The synthesized compounds were characterized by FT-IR
and UV-Vis. The results of FT-IR and UV-Vis spectra of the ligand and its metal
complexes confirm the formation of azomethine group (-C=N-NH) accompanied with
the absence of carbonyl group (C=O) and the formation of (M-N) and (M-S) bonds
with all metal complexes. The results assign that the ligand is neutral and
bidentate species witch coordinated via azomethine N and thione S with all
three metal ions. The antimicrobial activity of the ligand and its metal
complexes was carried out against four types of bacteria (Bacillus subtilis,
Pseudomonas aeruginosa, and Escherichia coli) and one fungus (Candida
ablicans) by using disc diffusion method. The results showed that the
ligand was inactive against one fungi (Candida ablicans) and three type
of bacteria (Escherichia coli, Pseudomonas aeruginosa and Bacillus
subtilis) and partially active against one type of bacteria (Staphylococcus
aureus), Ni (II) complex was inactive against all tested bacteria and
partially active against one fungi (Candida ablicans), Co (II) complex
was active against one type of bacteria (Escherichia coli) and one fungi
(Candida ablicans) and partially active against three type of bacteria (Bacillus
subtilis, Staphylococcus aureus, Pseudomonas aeruginosa ), Pb (II) complex
was active against one type of bacteria (Bacillus subtilis), partially
active against three type of bacteria (Staphylococcus aureus, Escherichia
coli and Pseudomonas aeruginosa) and one fungi. The study recommends
further work should be done to test these compounds against other types of
bacteria and fungi.
Pages:1-4
How to cite this article:
Mohammed Bahreldin Hussein, A Gobara, Mustafa Mohammad Ali Aldy "Nickel (II), cobalt (II) and lead (II) complexes of 4-hydroxy-3-methoxybenzaldehyde thiosemicarbazone synthesis; Characterization and antimicrobial activity ". International Journal of Chemistry Studies, Vol 8, Issue 1, 2024, Pages 1-4
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