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VOL. 7, ISSUE 1 (2023)
Biological activities and synthesis of metal-based heterocyclic compounds
Authors
Shalini Sharma, D S Seth
Abstract
The metal complexes of Cr(III) and Mn(II) with 2-aminothiazole (ATZ) and
azide ion ligands have been prepared by reacting chromium and manganese
nitrates with ligand 1:1 molar ratio for complex formation. The prepared
complexes have been characterized by using elemental analysis (C, H, N, M),
molar conductance, IR and UV-Vis spectral analysis. Also, their CV and TGA
behaviors have been studied. All the complexes have an octahedral structure.
The ligands coordinated to the metal ions through the nitrogen atoms of amino
group of 2-aminothiazole and azide ion. The antimicrobial activities of the
ligands and their metal complexes have been studied by using different
bacterial species viz., Escherichia coli, Lactobacillus brevis, Micrococcus
luteus, etc., and fungal species included viz., C.albicans, Aspergillus
niger etc., Moreover, the prepared complexes have been evaluated for
antioxidant activities and DNA binding properties. The complexes have larger
antioxidant activity as compared to free ligand. The DNA-binding properties
have been designed by fluorescence-emissions method. The obtained results
advise that the complexes effectively bind to DNA because of metal complexes
are well-known to speed up the drug action and the capability of healing agent
which can repeatedly be enhanced leading coordination with a metal ion.
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Pages:54-59
How to cite this article:
Shalini Sharma, D S Seth "Biological activities and synthesis of metal-based heterocyclic compounds". International Journal of Chemistry Studies, Vol 7, Issue 1, 2023, Pages 54-59
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