Flueggea virosa belongs to the family Phyllanthaceae, commonly called white berry-bush and commonly found in Southern part of Nigeria, and also in southern part of China. The leaves of F. virosa were extracted using soxhlet extractor with solvents of increasing polarity - hexane, ethyl acetate, acetone and methanol. The phytochemical analysis of the leave of Flueggea virosa were carried out using standard procedures and the results obtained reavealed that it contains phytochemical constituents such as alkaloids, flavonoids, anthraquinones, glycosides, tannins, terpenoids, saponins, steroids, and phenols. The quantitative phytochemical analysis showed highest concentration of alkaloids, which indicates that the leaves are rich in alkaloids. The antimicrobial screening of the crude extracts were carried out using the following microorganisms: Methicilin resistant Staphylococcus aureus (MRSA), Vancomycin resistant Enterococci (VRE), Staphylococcus aureus, Escherichia coli, Helicobacter pylori, Campylobacter jejuni, Salmonella typhi, Candida albicans, Candida krusei and Candida tropicalis. It was observed that MRSA, VRE, C. jejuni, and C. krusei were completely resistant to the plant’s crude extracts, while, S. aureus, E. coli, H. pylori, S. typhi, C. albicans, and C. tropicalis were susceptible to the crude extracts. The activities of the extracts against the microorganisms was concentration dependent, at a higher concentration of 10.00 mg/mL, the extracts were more bactericidal which implies that the plant possess antimicrobial properties as reported by the locals and can be a source of antimicrobial candidate.