The plant Curcuma Longa belongs to zingiberaccae family and is commonly called turmeric. The root of the plant are used by various traditional medical practitioners to treat several dis- eases such as inflammation, diarrhea, skin infection, minor cut or open wound, sore feet and others. The phytochemical screening of Curcuma Longa root extract revealed the presence of some secondary metabolites such as alkaloid, flavonoids, saponin, cardiac glycoside, tannins and many others. Quantification of phytochemicals by a Buck M910 gas chromatographic equipment with a flame ionization detector showed the root contained more of flavonoiod like Narigenin, Anthocyanin, Kaemfferol in combined concentration of (140.58ug/g) and Nari- genin recorded the concentration of (40.260) as the highest of the flavonoiod compound and steroids recorded the lowest concentration of (7.926). The proximate analysis revealed the presence of moisture, Ash, Fibre, fat, protein and carbohydrate content. Carbohydrate record- ed the highest concentration while Fibre recorded the lowest concentration. Elemental analysis was conducted using Agilent FS240AA Atomic Absorption Spectrophotometer revealed the presence of iron, sodium, magnesium, potassium and calcium. Potassium recorded the high- est concentration while Iron recorded the lowest concentration. The antimicrobial assay indi- cated resistance for S. enteric, E. Coli, A. Niger P. aeruginosa, C. albicans and A. Fumigatus and was susceptible to only the S. aureu, at 1000mg/L concentration. The minimum inhibitory concentration (MIC) showed moderate growth for staphylococcus aureus at 15mm. The pres- ence of the detected secondary metabolites in the plant confirmed the usefulness of the plant Curcuma Longa root against some pathogenic strain, which makes the plant a potential drug development candidate for treatment of diseases caused by this pathogen.