Six new Mg(II) ([Mg(sba)2]. 2H2O, 1), Fe(II) ([Fe(sba)2(H2O)4], 2), Co(II) ([Co(sba)2(H2O)4], 3), Ni(II) ([Ni(sba)2 (H2O)4]. 5H2O, 4), Cu(II) ([Cu(sba)2 (H2O)4]. 2H2O, 5) and Cd(II) ([Cd(sba)2 (H2O)4]. 5H2O, 6) complexes of 2,4-dichloro-5-sulfamoylbenzoic acid (Hsba) have been prepared. Metal compounds (1-6) characterized by AAS, elemental, FTIR, Uv-Vis., magnetic moment and molar conductivity measurements. The structures of the synthesized metal complexes were observed to be linear for 1 and octahedral for 2-6 according to analyses results. Moreover, antifungal and antibacterial activities of metal salt, Hsba and 1-6 were reviewed for their antifungal activities against Candida Albicans (ATCC 14053) (yeast), Candida parapisilosis (ATCC 22019) (yeast) and Candida krusei (ATCC 6258) (yeast) and antibacterial activities against Escherichia coli (ATCC 25922) (Gram negative), Enterococcus faecalis (ATCC 29212) (Gram positive), Staphylococcus aureus (ATCC 29213) (Gram positive). The results were check against with the antibiotic compounds, Fluconazole as antifungal agent and Cefepime, Vancomycin, Levofloxacin as antibacterial agent. Activity against all compounds bacteria and yeasts was observed.