Benzylideneacetophenone was synthesized using benzaldehyde and acetophenone. The melting point recorded 52-54oC, percentage yield 72.8% and Rf value of 0.68 in solvent system; ethylacetate: petroleum spirit (2:1) were determined. The sample was subjected to anti-seizure evaluations using mice as the phase one screening: Pentylenetetrazole (PTZ), Strychnine (STC) and Maximal Electroshock (MES) models at a dose of 500, 1000 and 1500 mg/kg. The phase two (II) assessment: the same doses of 500, 1000 and 1500 mg/kg/day treatment for 15 days using rats before induction of seizure using PTZ (100 mg/kg) and Strychnine (2 mg/kg) as convulsion inducing agents. The result of the anti-seizure effect showed that the sample delayed the onset of seizure in chemical model while in the MES decreased the duration of seizure. The result of the phase II models also confirmed that sample delayed the onset of seizure in strychnine compared to PTZ model appreciably at P<0.03-0.003 compared to control. These showed that the samples elicit anti-seizure effect in both phases of the experiment conducted this is line that flavonoid tend to have anti-seizure properties. The chemical structure of sample A was characterized using Infrared (IR), 1H, and 13C-NMR spectroscopic studies.