International Journal of Chemistry Studies

International Journal of Chemistry Studies


International Journal of Chemistry Studies
International Journal of Chemistry Studies
Vol. 5, Issue 1 (2021)

Kinetics and mechanism reaction of hydrolysis of mono-4-chloro, 3-methyl phenyl phosphate ester in acidic medium


Seema Kumari, Veena Kumari, BK Tiwari, RB Singh

Kinetics and mechanism of and hydrolysis of mono-4-chloro, 3- methyl phenyl phosphate has been carried out in the pH range, 1.24 to 7.46 in aq. dioxin media at 97 0.5.0C Neutral species although shown to be present by salt effect study. Which does not seem to participate in the reaction at the lowest pH value 1.24 examined. Mononegative species, however, in the pH region upto 7 gets hydrolysed unimolecularly. This is also evident from the low entropy value, isokinetic relationship ( ) and solvent effect studies and thus lends strong support for the intramolecular general acid catalysis by the hydroxyl group of the monoanion. The dinegative species is rather inert between pH 4 and 7. Its contribution to the overall rate becomes significant after pH 7. The reactivity depends largely upon the highly basic nature of the leaving group caused by +m effect of three halogen substituents. pK1and pK2 values have been determined to be 1. 17 and 6.8 respectively. The monoester and the parent compound have also been tested for their antifungal activity.
Download  |  Pages : 11-13
How to cite this article:
Seema Kumari, Veena Kumari, BK Tiwari, RB Singh. Kinetics and mechanism reaction of hydrolysis of mono-4-chloro, 3-methyl phenyl phosphate ester in acidic medium. International Journal of Chemistry Studies, Volume 5, Issue 1, 2021, Pages 11-13
International Journal of Chemistry Studies