Heterocyclic compounds are of immense interest due to their extensive occurrence in nature as well as their applicability in the pharmaceutical industry. Benzothiazole and its derivatives encompass an attractive heterocyclic class that displays practical applications ranging from mevdicine to photography and agriculture, among other things. This review focuses on the synthesis and specific applications of various benzothiazole cyanine dyes. Benzothiazole-containing heterocyclic structures are prominent throughout the literature and it is very important to acknowledge their efficacy and applicability as we discuss herein.