In this study, we report the synthesis of a new Mannich base derived from Maleic hydrazide and its transition metal complexes. Maleic hydrazide was aminomethylated by reacting with formaldehyde and N-methylpiperazine. The so formed base is complexed with transition metals. The structure of the synthesized compounds are confirmed by UV, IR, and ¹H NMR spectroscopic techniques. The antibacterial activity of the ligands and the complexes were examined using different bacterias.