Evaluation of physiochemical and pharmacokinetic ability of thirty five integrase inhibitors was carried out to determine the best drug candidates among them. SwissADME an online software was used in this study and the result obtained revealed that three inhibitors with high molecular weight above 500gmol-1 and high Topological polar surface area(TPSA) are unsuitable as drug candidates while compound 3 with the lowest molecular weight and TPSA is considered the best inhibitor for HIV integrase. The result of this study showed that these compounds are excellent inhibitors for HIV-1 Integrase with significant physiochemical properties and are useful for the development of new HIV-1 Integrase drugs.