Synthesis and antimicrobial activity of some compounds derived from diazo dyes
Mohammed Hadi Al–Douh, Elham Abdalrahem Bin Selim, Wedad Mohammed Al–Haik, Samia Mabrook Bin Mahram, Aisha Khalid Al–Bakri, Dehab Salim Al–Nohey, Khalid Saeed Sonbol
Three of diazo dye derivatives 12a-c were synthesized via the reaction of diazonium salts 10a-c with vanillin 11 in good yields. The prepared compounds were assigned by FTIR spectra, UV–Vis spectra and melting points determination. Compounds 12a-c were evaluated for antimicrobial activities employing three bacteria strains Staphylococcus aureus, Escherichia coli and Proteus mirabilis. Interesting compounds 12a and 12b showed selective significant activities to P. mirabilis bacteria. Moreover, 12b showed considerable activity at concentration 0.0625 mM (++ = IZ 13–19 mm). Finally, compound 12b showed antibacterial activity against S. aureus at concentration 0.25 mM and E. coli at concentrations of 0.25 mM and 0.125 mM.