Synthesis of New Heterocyclic Compounds from Reaction of N-Aryl Maleimide with Cinnamal aryl hydrazones and Their Antimicrobial Activity
Abdullah Abdalkarim Al–Shara′ey, Mohammed Hadi Al–Douh, Eman Ali Thabet, Younes Saif Gahnem
The methods of cycloaddition reaction between cinnamal aryl hydrazones 1 or 2 with N-Aryl Maleimide 3a-e to give 8-phenyl-4,11-bis(aryl)-1,4,11-triazatetracyclo [6,6,0,2,60,9,130] tetradecane-3,5,10,12-tetraone 4a-e and 5a-e in good yields. Some of the synthesized compounds were directed toward hydrogenation, hydrolysis and dehydrogenation reactions to afford the expected compounds 6a-c,e, 7a-e, 8b, 9a,b, 10a-e and 11a,b,d,e. The structural formulas for new synthesis compounds were assigned using chemical and physical methods as elemental analysis, mass spectroscopy, infrared and proton nuclear magnetic resonance spectroscopy. However, some of the synthesized compounds were studied against toward antimicrobial activity against some types of bacteria and fungi.