Vol. 2, Issue 2 (2018)
Rate acceleration of Baylis-Hillman reaction
Author(s): Dandamudi V Lenin
Abstract: In the organic chemistry carbon-carbon bond formations and functional group transformation strategies are very important aspects. The Baylis-Hillman reaction is a carbon-carbon bond forming reaction in the presence of tertiary amine catalyst. This reaction is a coupling at a-position of activated alkenes with electrophiles under the influence of a tertiary amine catalyst to form a densely functionalized molecule (Fig. 1) (essential components are electrophiles, activated alkene and catalytic source). The Baylis-Hillman reaction was discovered by American chemists A. B. Baylis and M. E. D. Hillman in the year 1973.