Vol. 2, Issue 2 (2018)
Synthesis, characterization & biological evaluation of mutual prodrugs of some selected NSAIDs
Author(s): Nidhi Sharma, Vijay Kumar Sharma, Anil Kumar Sahdev
Abstract: Non- Steroidal Anti- inflammatory Drugs (NSAIDS) are most widely used drugs because of their Analgesics, Anti-inflammatory & Antipyretic action. Along with these actions it also shows some gastrointestinal & ulcerogenic side effects. To overcoming these side effects it is essential to attach one other moiety with NSAIDs. Mutual prodrugs is a type of prodrug in which two pharmacologically active drugs attached to each other in such a way that each drug act as a promoiety/Carrier for others. In this way the action may be synergistic if they have same biological action or additional if they have different pharmacological action.