Vol. 2, Issue 1 (2018)
MicroRNA-9 expression is a prognostic biomarker for benign angiofibroma and malignant nasopharyngeal tumors
Author(s): Randa S Hana, Bahaa L Bawi
Abstract: In recent years, microRNAs have been shown to be involved in tumor pathogenesis and regulation of gene expression. The objective of the present study was to examine the expression level of microRNA-9 (miR-9) in 17 angiofibroma, 57 nasopharyngeal carcinoma and 60 control blood samples, using a real-time quantitative assay, and to investigate the relationships between miR-9 expression, clinic pathological features and the prognosis of these patients Results: A significant decrease in miR-9 expression (P=0.03) was observed in angiofibromas compared to controls and that decrease was significantly associated with clinical staging and complications (P < 0.05).Compared to angiofibroma and healthy samples, the expression levels of miR-9 in nasopharyngeal carcinoma were significantly decreased (P < 0.01) and were significantly associated with clinical stage and distant metastasis (P < 0.01). The Kaplan–Meier curve showed that patients with high miR-9 expression survived significantly longer than patients with low miR-9 expression (P <0.001). Furthermore, these levels were significantly higher in post-treatment samples than in pre-treatment samples (P < 0.01) in all patients. Conclusions: The findings of the present study suggested that decreased miR-9 expression has a strong correlation with the clinical staging and progression of nasopharyngeal angiofibroma and carcinoma and its low expression is a significant risk factor affecting cancer patients' survival, suggesting that it could be a valuable marker for prognosis of nasopharyngeal tumors.