International Journal of Chemistry Studies

International Journal of Chemistry Studies

ISSN: 2581-348X

Vol. 1, Issue 1 (2017)

A randomized single blinded preliminary clinical study on lipid lowering effect of a polyherbal compound in the management of hypercholesterolemia

Author(s): Abdul Hameed Ayshah Fazeenah, Mohammed Aleemuddeen Quamri
Abstract: Hypercholesterolemia is a common lipid metabolic disorder characterized by an abnormal concentration of lipids or lipoproteins in blood. Uncontrolled or improper treatment leads to complicated serious illnesses such as cardio vascular, cerebro vascular and peripheral vascular diseases. According to the World Health Organization a third of ischaemic heart disease is attributable to high cholesterol. Globally hypercholesterolemia is estimated to cause 56% of ischaemic heart diseases and about 4.4 million deaths per year. The objective of the study was to evaluate the efficacy and safety of Polyherbal compound in the management of hypercholesterolemia. A Randomized single blinded preliminary clinical study was conducted from February 2014 to August 2014 in the outpatient department of National Ayurveda Teaching Hospital, Borella. 30 patients of hypercholesterol, aged 40-60 years from both gender were selected. The patients were received 30ml of Polyherbal compound juice two times a day for 21 days with dietary restriction and moderate physical exercise for 45 minutes. The pre and post study effects were assessed by symptom reduction and laboratory reports. The results showed statistically significant reduction in total cholesterol (TC), serum triglycerides (TG), Low Density Lipoprotein (LDL), TC/LDL ratio and LDL/HDL ratio and increase of High Density Lipoprotein (HDL). Our results demonstrated that the Polyherbal compound has beneficial effects on reduce lipid profile without any adverse effects. Therefore, further high quality studies with large sample should be conducted to better understanding the effectiveness of Polyherbal compound on hypercholesterolemia.
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